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DEPTOR at the Nexus of Cancer, Metabolism, and Immunity

I. INTRODUCTION. The story of the mechanistic target of rapamycin (mTOR) is, as its name implies, intimately linked to the discovery of rapamycin, an antifungal macrolide produced by a soil bacteria collected on Easter Island in 1964 ().Following its isolation in the 1970s, rapamycin was shown to exhibit strong immunosuppressive, anti-neoplastic and anti-proliferative properties (10, 109, 170

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Lavatory-Undercounter_Transitional_LT641_TOTO

BM-00082 Dartmouth LT641 TOTO USA, Inc.

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References H NF-kB Transcription Factors Boston

He MX, He XF, Xie QZ, Chen FP and He SL (2003) Effect of angiotensin II on tissue factor expression in human peripheral blood monocytes and its mechanisms

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ComBio2017

The Medical Genome Reference Bank deep genomics of a disease-depleted, elderly Australian population. Pinese M, Lacaze P, Rath E, Kaplan W, Andrews D, The Aspree Investigator Group, The 45 and Up Study Collaborators, Barr M, Thomas DM and Dinger M. 935hairsp;am . Integrating human epidemiology and molecular biology in the era of big data

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Reactive Oxygen Species in Metabolic and Inflammatory

Shanmugasundaram K, Nayak BK, Friedrichs WE, Kaushik D, Rodriguez R, Block K. NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance. Nat

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The Lysosome and Intracellular Signalling SpringerLink

Pitt SJ, Funnell TM, Sitsapesan M, Venturi E, Rietdorf K, Ruas M, Ganesan A, Gosain R, Churchill GC, Zhu MX, Parrington J, Galione A, Sitsapesan R (2010) TPC2 is a novel NAADP-sensitive Ca 2 release channel, operating as a dual sensor of luminal pH and Ca 2 . J Biol Chem 285(45)3503935046.

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Therapeutic targets in triple negative breast cancer

Outcomes have improved significantly for many women diagnosed with breast cancer. For the heterogeneous group of tumours lacking expression of the oestrogen, progesterone and HER2 receptors, 'triple negative' breast cancers (TNBC), the prognosis overall has remained quite poor. When TNBC recurs, there is often little response to chemotherapy, and there are a few treatment options in this

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